Tim McGraw is in the very best form of his life at forty seven, due to a low-carb Paleo weight loss plan and rigorous CrossFit exercises. Strict weight-reduction plan also results in overeating as a result of it causes people to fully lose touch with their own internal starvation and fullness cues. The exception to the rule is the DOT1 family, members of which methylate K79 in the globular region of histone H3 and that are structurally not related to SET-domain proteins four - 6 Latest work means that SET-area-containing proteins methylate just a few proteins along with histones (see later)