As a coach, my purpose is to offer you the instruments that you must make a protracted-term dedication to fitness whereas preserving your quality of life. The exception to the rule is the DOT1 family, members of which methylate K79 in the globular region of histone H3 and that are structurally not associated to SET-domain proteins 4 - 6 Recent work means that SET-domain-containing proteins methylate just a few proteins in addition to histones (see later)