SPOT synthesis is not restricted to proteinogenic amino acids, several commercially out there modified amino acids additionally can be utilized for synthesis, permitting peptides to be modified earlier than and after the final cleavage of the side-chain safety group and, furthermore, it also allows incorporation of phosphorylated, methylated or acetylated amino acids eleven.

With a purpose to replicate, the herpes virus requires arginine , another amino acid that is frequent in foods and essential to human life